Skip to the content
Open ReactionLens
Browse the library

(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone

An aromatic amide, C21H19ClN2O2, 366.848 g/mol.

verified record, Organic — aromatic amide

Identifiers

Molecular formula
C₂₁H₁₉ClN₂O₂
Molecular weight
366.848 g/mol
Exact mass
366.113506 g/mol
IUPAC name
(6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone
SMILES
O=C(c1c[nH]c2cc(Cl)ccc12)N1CCC2(CC1)OCc1ccccc12
InChI
InChI=1S/C21H19ClN2O2/c22-15-5-6-16-17(12-23-19(16)11-15)20(25)24-9-7-21(8-10-24)18-4-2-1-3-14(18)13-26-21/h1-6,11-12,23H,7-10,13H2
InChIKey
FPWHCHLKTSMBLA-UHFFFAOYSA-N
Open in ReactionLensUse in reaction prediction

Calculated properties

Derived from the structure, not from a sample; kept apart from the measurements above.

Molecular weight
366.8 g/molcalculated · reference compound database
Average mass of one molecule, from reference compound database.
Exact mass
366.1135055 Dacalculated · reference compound database
Mass of the most common isotopic form.
XLogP3
3.4calculated · reference compound database
Estimated oil/water partition, computed by reference compound database.
Polar surface area
45.3 Ųcalculated · reference compound database
Polar surface area as computed by reference compound database.
Complexity
548calculated · reference compound database
A rough measure of how intricate the structure is.
H-bond donors
1calculated · reference compound database
H-bond acceptors
2calculated · reference compound database
logP
4.483calculated · chemistry engine
Estimated preference for oil over water. Higher means more oil-like.
Topological polar surface area
45.33 Ųcalculated · chemistry engine
Surface area from polar atoms; relates to how easily a molecule crosses membranes.
H-bond donors
1calculated · chemistry engine
Atoms that can donate a hydrogen bond.
H-bond acceptors
2calculated · chemistry engine
Atoms that can accept a hydrogen bond.
Rotatable bonds
1calculated · chemistry engine
Single bonds the molecule can freely twist around.
Molar refractivity
101.3552 cm³/molcalculated · chemistry engine
Relates to the molecule's polarisability.
Fraction sp³ carbons
0.2857calculated · chemistry engine
Share of carbon atoms with tetrahedral bonding.
QED drug-likeness
0.6896calculated · chemistry engine
Quantitative estimate of drug-likeness (0–1).

What it is made of

Elements

Percentages are of the molecular weight above, worked out the same way the molar mass calculator does it.

Structure

Heavy atoms, hydrogen excluded
26
Total atoms, hydrogen included
45
Rings
5
Aromatic rings
3
Stereocentres
0
Formal charge
0

Functional groups

  • Amide

    A carbonyl bonded directly to nitrogen.

  • Ether

    An oxygen bridging two carbons.

  • Halide (C–X)

    A halogen atom attached to carbon.

  • Aromatic ring

    A flat six-membered ring with delocalised electrons.

  • Aromatic ring (five-membered)

    A flat five-membered ring with delocalised electrons, such as furan, thiophene or pyrrole.

Matched by structural pattern, not by a measurement.

The molecule in three dimensions

Rotate and inspect the atoms. Loaded only when you ask, so the page stays light.

The drawing above is a diagram of what is bonded to what. A molecule is not flat, and the model here is one low-energy shape generated from the connectivity — useful for seeing which groups can reach each other, and not a measured structure. A real sample is a population of conformations, interconverting.

Reactions it appears in

No documented reaction with a written procedure and a source involves (6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone yet.

Other names for it

The systematic name on this record is (6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone.

The sources also call it CHEMBL3416861, SCHEMBL4360122, FPWHCHLKTSMBLA-UHFFFAOYSA-N, BDBM50077206.

Structurally related

Molecules sharing this formula, or whose fingerprint is at least 40% similar to this one. Similarity is Tanimoto on Morgan fingerprints over this library only — it is a measure of structural overlap, not of how alike they behave.

1'-[(6-chloro-1H-indol-3-yl)carbonyl]-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

C21H17ClN2O3

1'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

C21H16ClFN2O3

(4-amino-piperidin-1-yl)-(6-chloro-1H-indol-3-yl)-methanone

C14H16ClN3O

(6-Chloro-1H-indol-3-yl)[4-(2-fluorophenyl)piperazin-1-yl]methanone

C19H17ClFN3O

Seen alongside it in reaction records

Molecules that appear in the same recorded reactions as (6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone. This says nothing about structure: most of them are the bases, solvents, ligands and catalysts the chemistry needed, and they are here because somebody put them in the same flask.

1,4-Dibenzyl-2-(chloromethyl)piperazine

used as a reactant

C₁₉H₂₃ClN₂, 314.86 g/mol.

1'-({6-Chloro-1-[(1,4-dibenzylpiperazin-2-yl)methyl]-1H-indol-3-yl}carbonyl)-3H-spiro[2-benzofuran-1,4'-piperidine]

formed as a product

C₄₀H₄₁ClN₄O₂, 645.247 g/mol.

1'-{[6-Chloro-1-(2-morpholin-4-ylethyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine]

formed as a product

C₂₇H₃₀ClN₃O₃, 480.008 g/mol.

1'-{[6-Chloro-1-(oxiran-2-ylmethyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidine]

formed as a product

C₂₄H₂₃ClN₂O₃, 422.912 g/mol.

Where these values came from

compound record.

What this page does not claim

Identifiers are copied from the source record, measured values are reported as published, and calculated values are marked as calculated. Nothing here is a hazard, purity or handling assessment — how the library is checked.

Where to next

Molar mass calculator

Work with C21H19ClN2O2 in a calculation, with every element's contribution shown.

Molarity calculator

Grams of (6-chloro-1H-indol-3-yl)-spiro[1H-2-benzofuran-3,4'-piperidine]-1'-ylmethanone for a volume and a concentration, or the concentration a mass gives.

Open in ReactionLens

The full record in the workstation: every atom, every bond, and the reactions it appears in.