Guanine

C5H5N5O, 151.129 g/mol. Its structure, the values that were measured, the values that were calculated, and where each one came from.

verified recordOrganic — aromatic amine4 measured properties

Drawn from the SMILES. It shows how the atoms are connected — not a photograph of a molecule, and not its shape in space.

Identifiers

Molecular formula: C₅H₅N₅O
Molecular weight: 151.129 g/mol
Exact mass: 151.04941 g/mol
IUPAC name: 2-amino-3,7-dihydropurin-6-one
SMILES: Nc1nc2nc[nH]c2c(=O)[nH]1
InChI: InChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
InChIKey: UYTPUPDQBNUYGX-UHFFFAOYSA-N

Open in ReactionLens Use in reaction prediction

Both are open without an account.

Measured properties

Values somebody obtained from a sample and published. Where two sources report the same property they are both shown, in the units each used — a disagreement between them is information, and averaging it away would be inventing a number neither one gave.

Boiling Point: BOILING POINT: SUBLIMESmeasured · Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed. Boca Raton, Florida: CRC Press Inc., 1979., p. C-324
Melting Point: 360 dec °Cmeasured · PhysProp; 360 °C (DECOMP)measured · Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed. Boca Raton, Florida: CRC Press Inc., 1979., p. C-324; 360 °Cmeasured · reference compound database
Solubility: 2080 mg/L (at 37 °C)measured · YALKOWSKY,SH & DANNENFELSER,RM (1992); CRYSTALLINE POWDER; LOSES WATER @ 100 °C & HYDROGEN CHLORIDE @ 200 °C; PRACTICALLY INSOL IN WATER, ALC, ETHER; SOL IN ACIDULATED WATER /HYDROCHLORIDE/measured · The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 593; FREELY SOL IN DIL ACIDS & AQ POTASSIUM HYDROXIDE SOLN; SPARINGLY SOL IN ALCOHOL; ALMOST INSOL IN WATERmeasured · The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 593; SOL IN AMMONIUM HYDROXIDE & ALKALI; SLIGHTLY SOL IN ETHER; INSOL IN ACETIC ACID, SLIGHTLY SOL IN ETHERmeasured · Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed. Boca Raton, Florida: CRC Press Inc., 1979., p. C-324; 2.08 mg/mL at 37 °Cmeasured · reference compound database
LogP: -0.91measured · HANSCH,C ET AL. (1995); -0.91measured · HANSCH,C ET AL. (1995); -0.91measured · reference compound database

Calculated properties

Derived from the structure rather than from a sample. These are reproducible and they are not measurements: a calculated partition coefficient and a measured one can differ by a long way, and where both exist they are listed apart on purpose.

Molecular weight: 151.13 g/molcalculated · reference compound database; Average mass of one molecule, from reference compound database.
Exact mass: 151.0494098 Dacalculated · reference compound database; Mass of the most common isotopic form.
XLogP3: -1calculated · reference compound database; Estimated oil/water partition, computed by reference compound database.
Polar surface area: 96.2 Å²calculated · reference compound database; Polar surface area as computed by reference compound database.
Complexity: 225calculated · reference compound database; A rough measure of how intricate the structure is.
H-bond donors: 3calculated · reference compound database
H-bond acceptors: 2calculated · reference compound database
logP: -0.7716calculated · chemistry engine; Estimated preference for oil over water. Higher means more oil-like.
Topological polar surface area: 100.45 Å²calculated · chemistry engine; Surface area from polar atoms; relates to how easily a molecule crosses membranes.
H-bond donors: 3calculated · chemistry engine; Atoms that can donate a hydrogen bond.
H-bond acceptors: 4calculated · chemistry engine; Atoms that can accept a hydrogen bond.
Rotatable bonds: 0calculated · chemistry engine; Single bonds the molecule can freely twist around.
Molar refractivity: 38.9218 cm³/molcalculated · chemistry engine; Relates to the molecule's polarisability.
Fraction sp³ carbons: 0calculated · chemistry engine; Share of carbon atoms with tetrahedral bonding.
QED drug-likeness: 0.4598calculated · chemistry engine; Quantitative estimate of drug-likeness (0–1).

What it is made of

Elements

N Nitrogen5 atoms · 46.3% by mass
C Carbon5 atoms · 39.7% by mass
O Oxygen1 atom · 10.6% by mass
H Hydrogen5 atoms · 3.3% by mass

Percentages are of the molecular weight above, worked out the same way the molar mass calculator does it.

Structure

Heavy atoms, hydrogen excluded: 11
Total atoms, hydrogen included: 16
Rings: 2
Aromatic rings: 2
Stereocentres: 0
Formal charge: 0

Functional groups

Primary aromatic amine
An –NH2 group attached directly to an aromatic ring, as in aniline. Much less basic than an alkyl amine, because the lone pair is delocalised into the ring.
Aromatic ring
A flat six-membered ring with delocalised electrons.
Aromatic ring (five-membered)
A flat five-membered ring with delocalised electrons, such as furan, thiophene or pyrrole.

Matched by structural pattern, not by a measurement.

The molecule in three dimensions

Rotate and inspect the atoms. Loaded only when you ask, so the page stays light.

The drawing above is a diagram of what is bonded to what. A molecule is not flat, and the model here is one low-energy shape generated from the connectivity — useful for seeing which groups can reach each other, and not a measured structure. A real sample is a population of conformations, interconverting.

Reactions it appears in

No documented reaction with a written procedure and a source involves Guanine yet.

Other names for it

The systematic name on this record is 2-amino-3,7-dihydropurin-6-one.

The sources also call it 2-Amino-6-hydroxypurine, 2-Aminohypoxanthine, Guanin, Mearlmaid, Guanine enol, Pearl essence, Stella Polaris, Dew Pearl, Naturon, Natural white 1, Natural pearl essence, 6H-Purin-6-one, 2-amino-1,7-dihydro-.

Structurally related

Nothing structurally close to Guanine has a page here yet.

Where these values came from

reference compound database764
compound record
chemistry engine
structure perception

compound record.

What this page does not claim

The identifiers are what the source record holds, copied rather than recomputed. Measured values are reported as their source gave them, units and all; calculated values are marked as calculated and are not measurements. Where a field is absent the page says so, because a blank cell reads as a zero and a guessed value reads as a fact.

Nothing here is a hazard assessment, a purity statement or advice about handling a sample. A flash point quoted from a safety database is a number somebody published, not a judgement by us about whether this molecule is safe for what you intend.