Hexamethylphosphoramide

An organic compound, C6H18N3OP, 179.204 g/mol. Boiling point 233 °C @ 760 MM HG, melting point 5-7 °C, as published.

verified recordOrganic compound8 measured properties

Identifiers

Molecular formula: C₆H₁₈N₃OP
Molecular weight: 179.204 g/mol
Exact mass: 179.118749 g/mol
IUPAC name: N-[bis(dimethylamino)phosphoryl]-N-methylmethanamine
SMILES: CN(C)P(=O)(N(C)C)N(C)C
InChI: InChI=1S/C6H18N3OP/c1-7(2)11(10,8(3)4)9(5)6/h1-6H3
InChIKey: GNOIPBMMFNIUFM-UHFFFAOYSA-N

Open in ReactionLens Use in reaction prediction

Measured properties

Published measurements, each with its source. Two readings of one property are both shown, in the units each used.

Boiling Point: 451 °F at 760 mmHg (NTP, 1992)measured · CAMEO Chemicals; 233 °C @ 760 MM HGmeasured · Hazardous Substances Data Bank (HSDB)
Melting Point: 41 to 45 °F (NTP, 1992)measured · CAMEO Chemicals; FP: 5-7 °Cmeasured · Hazardous Substances Data Bank (HSDB)
Density: 1.024 at 77 °F (NTP, 1992) - Denser than water; will sinkmeasured · CAMEO Chemicals; 1.03 @ 20 °Cmeasured · Hazardous Substances Data Bank (HSDB)
Solubility: greater than or equal to 100 mg/mL at 64 °F (NTP, 1992)measured · CAMEO Chemicals; MISCIBLE WITH WATER & WITH MOST ORG LIQ; IMMISCIBLE WITH HIGH-BOILING SATURATED HYDROCARBONSmeasured · Hazardous Substances Data Bank (HSDB)
Vapor Pressure: 0.07 mmHg at 77 °F (NTP, 1992)measured · CAMEO Chemicals; 0.03 [mmHg]measured · Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
LogP: 0.09measured · SangsterLogP
Flash Point: 222 °F (NTP, 1992)measured · CAMEO Chemicals; NIOSH REL = lowest feasible conc. 222 °Fmeasured · Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Refractive Index: INDEX OF REFRACTION: 1.4572 @ 21 °C/Dmeasured · Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 734

Calculated properties

Derived from the structure, not from a sample; kept apart from the measurements above.

Molecular weight: 179.2 g/molcalculated · reference compound database; Average mass of one molecule, from reference compound database.
Exact mass: 179.1187492 Dacalculated · reference compound database; Mass of the most common isotopic form.
XLogP3: 0.3calculated · reference compound database; Estimated oil/water partition, computed by reference compound database.
Polar surface area: 26.8 Å²calculated · reference compound database; Polar surface area as computed by reference compound database.
Complexity: 139calculated · reference compound database; A rough measure of how intricate the structure is.
H-bond donors: 0calculated · reference compound database
H-bond acceptors: 4calculated · reference compound database
logP: 0.7793calculated · chemistry engine; Estimated preference for oil over water. Higher means more oil-like.
Topological polar surface area: 26.79 Å²calculated · chemistry engine; Surface area from polar atoms; relates to how easily a molecule crosses membranes.
H-bond donors: 0calculated · chemistry engine; Atoms that can donate a hydrogen bond.
H-bond acceptors: 1calculated · chemistry engine; Atoms that can accept a hydrogen bond.
Rotatable bonds: 3calculated · chemistry engine; Single bonds the molecule can freely twist around.
Molar refractivity: 48.6675 cm³/molcalculated · chemistry engine; Relates to the molecule's polarisability.
Fraction sp³ carbons: 1calculated · chemistry engine; Share of carbon atoms with tetrahedral bonding.
QED drug-likeness: 0.5981calculated · chemistry engine; Quantitative estimate of drug-likeness (0–1).

What it is made of

Elements

C Carbon6 atoms · 40.2% by mass
N Nitrogen3 atoms · 23.4% by mass
P Phosphorus1 atom · 17.3% by mass
H Hydrogen18 atoms · 10.1% by mass
O Oxygen1 atom · 8.9% by mass

Percentages are of the molecular weight above, worked out the same way the molar mass calculator does it.

Structure

Heavy atoms, hydrogen excluded: 11
Total atoms, hydrogen included: 29
Rings: 0
Aromatic rings: 0
Stereocentres: 0
Formal charge: 0

The molecule in three dimensions

Rotate and inspect the atoms. Loaded only when you ask, so the page stays light.

The drawing above is a diagram of what is bonded to what. A molecule is not flat, and the model here is one low-energy shape generated from the connectivity — useful for seeing which groups can reach each other, and not a measured structure. A real sample is a population of conformations, interconverting.

Reactions it appears in

No documented reaction with a written procedure and a source involves Hexamethylphosphoramide yet.

Other names for it

The systematic name on this record is N-[bis(dimethylamino)phosphoryl]-N-methylmethanamine.

The sources also call it HMPA, Hexamethylphosphoric triamide, Hexametapol, Hempa, HMPTA, Hexamethylphosphoric acid triamide, Phosphoric hexamethyltriamide, Hexamethylphosphorotriamide, Eastman Inhibitor HPT, Phosphoric triamide, hexamethyl-, Hexamethylphosphotriamide.

Structurally related

Nothing structurally close to Hexamethylphosphoramide has a page here yet.

Seen alongside it in reaction records

Molecules that appear in the same recorded reactions as Hexamethylphosphoramide. This says nothing about structure: most of them are the bases, solvents, ligands and catalysts the chemistry needed, and they are here because somebody put them in the same flask.

1,4-Dimethoxy-2,5-bis(methoxymethoxy)-3-methylthiobenzene

formed as a product

C₁₃H₂₀O₆S, 304.364 g/mol.

(S)-8-Bromo-9-fluoro-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic Acid

used as a reactant

C₁₄H₁₁BrFNO₃, 340.148 g/mol.

1,4-Dimethoxy-2,5-bis(methoxymethoxy)benzene

used as a reactant

C₁₂H₁₈O₆, 258.27 g/mol.

Where these values came from

reference compound database12679
compound record
chemistry engine
structure perception

compound record.

What this page does not claim

Identifiers are copied from the source record, measured values are reported as published, and calculated values are marked as calculated. Nothing here is a hazard, purity or handling assessment — how the library is checked.