Prazosin metabolite M6

An aromatic amide, C18H19N5O4, 369.381 g/mol.

verified recordOrganic — aromatic amide

Identifiers

Molecular formula: C₁₈H₁₉N₅O₄
Molecular weight: 369.381 g/mol
Exact mass: 369.143704 g/mol
IUPAC name: [4-(4-amino-7-hydroxy-6-methoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
SMILES: COc1cc2c(N)nc(N3CCN(C(=O)c4ccco4)CC3)nc2cc1O
InChI: InChI=1S/C18H19N5O4/c1-26-15-9-11-12(10-13(15)24)20-18(21-16(11)19)23-6-4-22(5-7-23)17(25)14-3-2-8-27-14/h2-3,8-10,24H,4-7H2,1H3,(H2,19,20,21)
InChIKey: RORKKAHCKPETLK-UHFFFAOYSA-N

Open in ReactionLens Use in reaction prediction

Calculated properties

Derived from the structure, not from a sample; kept apart from the measurements above.

Molecular weight: 369.4 g/molcalculated · reference compound database; Average mass of one molecule, from reference compound database.
Exact mass: 369.1437041 Dacalculated · reference compound database; Mass of the most common isotopic form.
XLogP3: 1.7calculated · reference compound database; Estimated oil/water partition, computed by reference compound database.
Polar surface area: 118 Å²calculated · reference compound database; Polar surface area as computed by reference compound database.
Complexity: 530calculated · reference compound database; A rough measure of how intricate the structure is.
H-bond donors: 2calculated · reference compound database
H-bond acceptors: 8calculated · reference compound database
logP: 1.4816calculated · chemistry engine; Estimated preference for oil over water. Higher means more oil-like.
Topological polar surface area: 117.95 Å²calculated · chemistry engine; Surface area from polar atoms; relates to how easily a molecule crosses membranes.
H-bond donors: 2calculated · chemistry engine; Atoms that can donate a hydrogen bond.
H-bond acceptors: 8calculated · chemistry engine; Atoms that can accept a hydrogen bond.
Rotatable bonds: 3calculated · chemistry engine; Single bonds the molecule can freely twist around.
Molar refractivity: 98.9917 cm³/molcalculated · chemistry engine; Relates to the molecule's polarisability.
Fraction sp³ carbons: 0.2778calculated · chemistry engine; Share of carbon atoms with tetrahedral bonding.
QED drug-likeness: 0.7127calculated · chemistry engine; Quantitative estimate of drug-likeness (0–1).

What it is made of

Elements

C Carbon18 atoms · 58.5% by mass
N Nitrogen5 atoms · 19.0% by mass
O Oxygen4 atoms · 17.3% by mass
H Hydrogen19 atoms · 5.2% by mass

Percentages are of the molecular weight above, worked out the same way the molar mass calculator does it.

Structure

Heavy atoms, hydrogen excluded: 27
Total atoms, hydrogen included: 46
Rings: 4
Aromatic rings: 3
Stereocentres: 0
Formal charge: 0

Functional groups

Amide
A carbonyl bonded directly to nitrogen.
Phenol
An –OH group attached to an aromatic ring.
Ether
An oxygen bridging two carbons.
Primary aromatic amine
An –NH2 group attached directly to an aromatic ring, as in aniline. Much less basic than an alkyl amine, because the lone pair is delocalised into the ring.
Tertiary aromatic amine
A nitrogen bonded to an aromatic ring and two other carbons.
Aromatic ring
A flat six-membered ring with delocalised electrons.
Aromatic ring (five-membered)
A flat five-membered ring with delocalised electrons, such as furan, thiophene or pyrrole.

Matched by structural pattern, not by a measurement.

The molecule in three dimensions

Rotate and inspect the atoms. Loaded only when you ask, so the page stays light.

The drawing above is a diagram of what is bonded to what. A molecule is not flat, and the model here is one low-energy shape generated from the connectivity — useful for seeing which groups can reach each other, and not a measured structure. A real sample is a population of conformations, interconverting.

Reactions it appears in

No documented reaction with a written procedure and a source involves Prazosin metabolite M6 yet.

Other names for it

The systematic name on this record is [4-(4-amino-7-hydroxy-6-methoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone.

The sources also call it 7-Desmethyl prazosin, VKZ5L84Q39, UNII-VKZ5L84Q39, 7-O-demethyl Prazosin, CHEMBL3302374, SCHEMBL14376918.

Structurally related

Nothing structurally close to Prazosin metabolite M6 has a page here yet.

Where these values came from

reference compound database136498753
compound record
chemistry engine
structure perception

compound record.

What this page does not claim

Identifiers are copied from the source record, measured values are reported as published, and calculated values are marked as calculated. Nothing here is a hazard, purity or handling assessment — how the library is checked.