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Tetrahydrothiophene

C4H8S, 88.175 g/mol. Its structure, the values that were measured, the values that were calculated, and where each one came from.

verified recordOrganic compound8 measured properties

Drawn from the SMILES. It shows how the atoms are connected — not a photograph of a molecule, and not its shape in space.

Identifiers

Molecular formula
C₄H₈S
Molecular weight
88.175 g/mol
Exact mass
88.034671 g/mol
IUPAC name
thiolane
SMILES
C1CCSC1
InChI
InChI=1S/C4H8S/c1-2-4-5-3-1/h1-4H2
InChIKey
RAOIDOHSFRTOEL-UHFFFAOYSA-N

Both are open without an account.

Measured properties

Values somebody obtained from a sample and published. Where two sources report the same property they are both shown, in the units each used — a disagreement between them is information, and averaging it away would be inventing a number neither one gave.

Boiling Point
121.12 °C @ 760 MM HGmeasured · Hazardous Substances Data Bank (HSDB)
119-121 °Cmeasured · ILO-WHO International Chemical Safety Cards (ICSCs)
Melting Point
-96.16 °Cmeasured · Hazardous Substances Data Bank (HSDB)
-96.2 °Cmeasured · ILO-WHO International Chemical Safety Cards (ICSCs)
Density
0.9987 @ 20 °C/4 °Cmeasured · Hazardous Substances Data Bank (HSDB)
Relative density (water = 1): 1.0measured · ILO-WHO International Chemical Safety Cards (ICSCs)
Solubility
INSOLUBLE IN WATER; SOL IN ALL PROPORTIONS IN ALCOHOL, ETHER, ACETONE, BENZENE, IN ORGANIC SOLVENTSmeasured · Hazardous Substances Data Bank (HSDB)
Solubility in water: nonemeasured · ILO-WHO International Chemical Safety Cards (ICSCs)
Vapor Pressure
18.4 [mmHg]measured · Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Vapor pressure, kPa at 25 °C: 2.4measured · ILO-WHO International Chemical Safety Cards (ICSCs)
LogP
1.8 (estimated by method of Leo et al, 1971).measured · Hazardous Substances Data Bank (HSDB)
1.8measured · ILO-WHO International Chemical Safety Cards (ICSCs)
Flash Point
55 °F (12 °C)measured · Hazardous Substances Data Bank (HSDB)
12 °Cmeasured · ILO-WHO International Chemical Safety Cards (ICSCs)
Refractive Index
MAXIMUM ABSORPTION (ALCOHOL): 240 NM SHOULDER (LOG E= 1.7); INDEX OF REFRACTION: 1.5048 @ 20 °C/D; SADTLER REFERENCE NUMBER 133 (NMR, JEOL, 100 MC SPECTRA)measured · Weast, R.C. (ed.). Handbook of Chemistry and Physics. 60th ed. Boca Raton, Florida: CRC Press Inc., 1979., p. C-516

Calculated properties

Derived from the structure rather than from a sample. These are reproducible and they are not measurements: a calculated partition coefficient and a measured one can differ by a long way, and where both exist they are listed apart on purpose.

Molecular weight
88.17 g/molcalculated · reference compound database
Average mass of one molecule, from reference compound database.
Exact mass
88.03467143 Dacalculated · reference compound database
Mass of the most common isotopic form.
XLogP3
1.4calculated · reference compound database
Estimated oil/water partition, computed by reference compound database.
Polar surface area
25.3 Ųcalculated · reference compound database
Polar surface area as computed by reference compound database.
Complexity
22calculated · reference compound database
A rough measure of how intricate the structure is.
H-bond donors
0calculated · reference compound database
H-bond acceptors
1calculated · reference compound database
logP
1.5134calculated · chemistry engine
Estimated preference for oil over water. Higher means more oil-like.
Topological polar surface area
0 Ųcalculated · chemistry engine
Surface area from polar atoms; relates to how easily a molecule crosses membranes.
H-bond donors
0calculated · chemistry engine
Atoms that can donate a hydrogen bond.
H-bond acceptors
1calculated · chemistry engine
Atoms that can accept a hydrogen bond.
Rotatable bonds
0calculated · chemistry engine
Single bonds the molecule can freely twist around.
Molar refractivity
26.559 cm³/molcalculated · chemistry engine
Relates to the molecule's polarisability.
Fraction sp³ carbons
1calculated · chemistry engine
Share of carbon atoms with tetrahedral bonding.
QED drug-likeness
0.4323calculated · chemistry engine
Quantitative estimate of drug-likeness (0–1).

What it is made of

Elements

Percentages are of the molecular weight above, worked out the same way the molar mass calculator does it.

Structure

Heavy atoms, hydrogen excluded
5
Total atoms, hydrogen included
13
Rings
1
Aromatic rings
0
Stereocentres
0
Formal charge
0

The molecule in three dimensions

Rotate and inspect the atoms. Loaded only when you ask, so the page stays light.

The drawing above is a diagram of what is bonded to what. A molecule is not flat, and the model here is one low-energy shape generated from the connectivity — useful for seeing which groups can reach each other, and not a measured structure. A real sample is a population of conformations, interconverting.

Reactions it appears in

No documented reaction with a written procedure and a source involves Tetrahydrothiophene yet.

Other names for it

The systematic name on this record is thiolane.

The sources also call it Thiolane, Thiophane, Thiophene, tetrahydro-, Thiacyclopentane, Tetramethylene sulfide, Thilane, Tetrahydrothiophen, Tetramethylenesulfide, Thiofan, Pennodorant 1013, Tetrahydrothiofen.

Structurally related

Molecules sharing this formula, or whose fingerprint is at least 40% similar to this one. Similarity is Tanimoto on Morgan fingerprints over this library only — it is a measure of structural overlap, not of how alike they behave.

Seen alongside it in reaction records

Molecules that appear in the same recorded reactions as Tetrahydrothiophene. This says nothing about structure: most of them are the bases, solvents, ligands and catalysts the chemistry needed, and they are here because somebody put them in the same flask.

Where these values came from

compound record.

What this page does not claim

The identifiers are what the source record holds, copied rather than recomputed. Measured values are reported as their source gave them, units and all; calculated values are marked as calculated and are not measurements. Where a field is absent the page says so, because a blank cell reads as a zero and a guessed value reads as a fact.

Nothing here is a hazard assessment, a purity statement or advice about handling a sample. A flash point quoted from a safety database is a number somebody published, not a judgement by us about whether this molecule is safe for what you intend.