Nucleophilic aromatic substitution by an alcohol or thiol
An alcohol, a phenol or a thiol displaces a halide from a ring that is pulled on hard enough to accept it.
mechanism writtenBalanced: every atom is accounted for
What it needs, and what it gives
- Reaction class
- Nucleophilic aromatic substitution
- A base to deprotonate the nucleophile, warm, in a polar aprotic solvent.
- balanced — the co-products are written out, not dropped
- Mechanism
- none written
How it is thought to happen
No mechanism is written for this class
The transformation is applied and tested, but no canonical pathway has been written for it yet. Rather than generate a plausible-looking set of arrows, the platform offers nothing here. What it does claim — which bonds change — is read from the transformation itself and does not depend on a mechanism.
Try it on your own structures
Enter your reactants in the Reaction Lab. If this transformation matches what you drew, it is applied and the outcome is shown next to the records that back it — with the count of documented reactions doing the same thing on substrates like yours, rather than a confidence score.