Buchwald–Hartwig amination, record ord-00b95f6f20354bb6923efd18c2b3c116
One recorded run of this reaction. Below is what the source recorded, and nothing added to it.
What was in the flask
| Role | Species | Formula | Yield |
|---|---|---|---|
| Reactant | 2-Bromopyridine | C₅H₄BrN | |
| Reactant | 1,4-Dioxa-8-azaspiro(4.5)decane | C₇H₁₃NO₂ | |
| Reagent | sodium 2-methylpropan-2-olate | C₄H₉NaO | |
| Catalyst | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | C₃₃H₄₉P | |
| Catalyst | Palladium (II) acetate | C₄H₈O₄Pd | |
| Product | 8-(2-Pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane | C₁₂H₁₆N₂O₂ | 66.56% |
Conditions
Yield
- 67% of 8-(2-Pyridinyl)-1,4-dioxa-8-azaspiro[4.5]decane.
Procedure
Copied from the source record, unedited
The same procrdure as EN03653-93-01.
The source
This record comes from experimental reaction archive (ord-00b95f6f20354bb6923efd18c2b3c116). Open the source and check it against what is on this page.
experimental reaction archive record ord-00b95f6f20354bb6923efd18c2b3c116 from dataset "750 AstraZeneca ELN dataset" (url: https://chemrxiv.org/engage/chemrxiv/article-details/60c9e3f37792a23bfdb2d471). No atom mapping is provided by the source.
How to read this record
This is one experiment, not a rule. It says that on one occasion these species were combined under these conditions and this came out. It does not say the reaction will give the same result on your substrate, and nothing on the page has been generalised into a claim that it would.
The pathway is a separate question, kept on separate pages. A mechanism here is the canonical arrow pushing for a class, run on real structures and labelled rule-derived. It is not evidence, and this record is not a mechanism.