Procedure (from the source record): (4-fluorophenyl)methanamine (67.3 mg, 0.54 mmol), 4-chloro-N- phenylpyridin-2-amine (100 mg, 0.49 mmol) and sodium 2-methylpropan-2-olate (94 mg, 0.98 mmol) were suspended in DMA (2 mL) and sealed into a microwave tube. Nitrogen was bubbled through the reaction mixture for 5 minutes. (R)-(-)-1-[(S)-2-(DICYCLOHEXYLPHOSPHINO)FERROCENYL]ETHYLDI-T-BUTYLPHOSPHINE (32
Clc1ccnc(Nc2ccccc2)c1.NCc1ccc(F)cc1>CC(C)(C)[O-].[Na+].CC(=O)N(C)C.C1CCCC1.CC(C1CCCC1P(C1CCCCC1)C1CCCCC1)P(C(C)(C)C)C(C)(C)C.[Fe].CC(=O)O.CC(=O)O.[Pd]>Fc1ccc(CN…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.FC(F)(F)c1ccc(Br)cc1>CS(C)=O.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C(C)(C)C)(C(C)(C)C)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c(C(C)C)c1.CS(C)=O.CS…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.FC(F)(F)c1ccc(I)cc1>CS(C)=O.COc1ccc(OC)c(P(C23CC4CC(CC(C4)C2)C3)(C23CC4CC(CC(C4)C2)C3)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c1-c1c(C(C)C…
Procedure (from the source record): 2-(2,5-dichloropyridin-4-ylamino)-N-methoxybenzamide (200 mg, 0.64 mmol), 1-isopropyl-3-methyl-1H-pyrazol-5-amine (178 mg, 1.28 mmol) and cesium carbonate (313 mg, 0.96 mmol) were suspended in 1,4-dioxane (3 mL). Nitrogen was bubbled through mixture for 10 minutes. (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (27.8 mg, 0.05 mmol) and diacetoxypallad
CONC(=O)c1ccccc1Nc1cc(Cl)ncc1Cl.Cc1cc(N)n(C(C)C)n1>O=C([O-])[O-].[Cs+].[Cs+].C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CC(=O)O…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.CCc1ccc(Cl)cc1>CS(C)=O.COc1ccc(OC)c(P(C(C)(C)C)(C(C)(C)C)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O.CS…
Procedure (from the source record): The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate
CC(N)CCc1ccccc1.Brc1cccnc1>COc1ccc(OC)c(P(C2CCCCC2)(C2CCCCC2)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(C)(=O)=O)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O.CS(C)=O.CN1CCCN2CC…
Procedure (from the source record): The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate
Nc1ccccc1.Brc1cccnc1>CC(C1=C(P(C2CCCCC2)(C2CCCCC2)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(C)(=O)=O)C([Fe]C2C=CC=C2)C=C1)P(C(C)(C)C)C(C)(C)C.CS(C)=O.CS(C)=O.CN(C)C(=NC(…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.CCc1ccc(Br)cc1>CS(C)=O.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)(C2CCCCC2)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c(C(C)C)c1.CS(C)=O.CS(C)=O.…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.Brc1cccnc1>CS(C)=O.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)(C2CCCCC2)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c(C(C)C)c1.CS(C)=O.CS(C)=O.CCN=…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.Ic1ccccn1>CS(C)=O.COc1ccc(OC)c(P(C(C)(C)C)(C(C)(C)C)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O.CS(C)=O…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.Brc1ccccn1>CS(C)=O.COc1ccc(OC)c(P(C23CC4CC(CC(C4)C2)C3)(C23CC4CC(CC(C4)C2)C3)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.FC(F)(F)c1ccc(Br)cc1>CS(C)=O.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)(C2CCCCC2)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c(C(C)C)c1.CS(C)=O.CS…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.Clc1cccnc1>CS(C)=O.COc1ccc(OC)c(P(C(C)(C)C)(C(C)(C)C)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O.CS(C)=…
Procedure (from the source record): _EN06995-11\Reaction_ and many others **_Aim:-_ prepare target for further use.** 1-iodo-3-(trifluoromethyl)benzene (0.215 ml, 1.49 mmol), 5-bromo-4-methoxypyrimidin-2-amine (0.254 g, 1.24 mmol), PALLADIUM(II) ACETATE (0.014 g, 0.06 mmol), rac-2,2'-bis(diphenylphosphino)-1,1'-binaphthalene (0.054 g, 0.09 mmol) and cesium carbonate (0.487 g, 1.49 mmol) were mix
FC(F)(F)c1cccc(I)c1.COc1nc(N)ncc1Br>O=C([O-])[O-].[Cs+].[Cs+].Cc1ccccc1.c1ccc(P(c2ccccc2)c2ccc3ccccc3c2-c2c(P(c3ccccc3)c3ccccc3)ccc3ccccc23)cc1.CC(=O)O.CC(=O)O.…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.FC(F)(F)c1ccc(Br)cc1>CS(C)=O.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C(C)(C)C)(C(C)(C)C)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c(C(C)C)c1.CS(C)=O.CS…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.Ic1cccnc1>CS(C)=O.COc1ccc(OC)c(P(C23CC4CC(CC(C4)C2)C3)(C23CC4CC(CC(C4)C2)C3)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.COc1ccc(Cl)cc1>CS(C)=O.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C(C)(C)C)(C(C)(C)C)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c(C(C)C)c1.CS(C)=O.CS(C)=O.…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.Brc1cccnc1>CS(C)=O.COc1ccc(OC)c(P(C23CC4CC(CC(C4)C2)C3)(C23CC4CC(CC(C4)C2)C3)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.Clc1ccccn1>CS(C)=O.COc1ccc(OC)c(P(C(C)(C)C)(C(C)(C)C)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O.CS(C)=…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.FC(F)(F)c1ccc(I)cc1>CS(C)=O.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)(C2CCCCC2)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c(C(C)C)c1.CS(C)=O.CS(…
Procedure (from the source record): Palladium(II) acetate (6.68 mg, 0.03 mmol), 2-(Dicyclohexylphosphino)biphenyl (10.42 mg, 0.03 mmol) and Cesium carbonate (0.388 g, 1.19 mmol) were put in a 5 mL microwave vial and sealed. The vial was flushed with argon. (R)-2-chloro-6-methyl-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine (0.082 g, 0.30 mmol) in DME (5 mL) was added to the vial. The re
CN1Cc2cnc(Cl)nc2O[C@H](c2ccccc2)C1.COc1cc(N)ccc1-n1cnc(C)c1>O=C([O-])[O-].[Cs+].[Cs+].COCCOC.c1ccc(-c2ccccc2P(C2CCCCC2)C2CCCCC2)cc1.CC(=O)O.CC(=O)O.[Pd]>COc1cc(…
Procedure (from the source record): 2,5-dichloro-4-iodopyridine (10.4 g, 37.97 mmol), 2-amino-N-methoxybenzamide (6.63 g, 39.87 mmol), cesium carbonate (14.85 g, 45.57 mmol) and (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (1.648 g, 2.85 mmol) were suspended in 1,4-dioxane (130 mL). Nitrogen was bubbled through the mixture for 10 minutes then diacetoxypalladium (0.426 g, 1.90 mmol) wa
Clc1cc(I)c(Cl)cn1.CONC(=O)c1ccccc1N>O=C([O-])[O-].[Cs+].[Cs+].C1COCCO1.CC1(C)c2cccc(P(c3ccccc3)c3ccccc3)c2Oc2c(P(c3ccccc3)c3ccccc3)cccc21.CC(=O)O.CC(=O)O.[Pd]>C…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.COc1ccc(Cl)cc1>CS(C)=O.COc1ccc(OC)c(P(C23CC4CC(CC(C4)C2)C3)(C23CC4CC(CC(C4)C2)C3)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C…
Procedure (from the source record): These solutions were added to a 384-
well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose
each of these solutions (200 nL each) into a 1536-well plate.
Cc1ccc(N)cc1.COc1ccc(Br)cc1>CS(C)=O.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C(C)(C)C)(C(C)(C)C)->[Pd]2(<-Nc3ccccc3-c3ccccc32)OS(=O)(=O)C(F)(F)F)c(C(C)C)c1.CS(C)=O.CS(C)=O.…
A selection of the distinct transformations in this class. The rest are reachable through the Reaction Lab by searching your own structures.
