Buchwald–Hartwig amination, record ord-d1da8942a5fd4744b25120701e88bd1a
One recorded run of this reaction. Below is what the source recorded, and nothing added to it.
What was in the flask
| Role | Species | Formula | Yield |
|---|---|---|---|
| Reactant | O=S(=O)(c1ccco1)N1CCc2c(ccnc2Cl)C1 | C₁₂H₁₁ClN₂O₃S | |
| Reactant | 3-Aminoquinoline | C₉H₈N₂ | |
| Reagent | sodium 2-methylpropan-2-olate | C₄H₉NaO | |
| Catalyst | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | C₃₉H₃₂OP₂ | |
| Catalyst | Bis(dibenzylideneacetone)palladium | C₅₁H₄₂O₃Pd₂ | |
| Solvent | tert-Butanol | C₄H₁₀O | |
| Product | 6-(furan-2-ylsulfonyl)-N-quinolin-3-yl-7,8-dihydro-5H-2,6-naphthyridin-1-amine | C₂₁H₁₈N₄O₃S | 9.8% |
Conditions
- Temperature
- 110 °C
Yield
- 10% of 6-(furan-2-ylsulfonyl)-N-quinolin-3-yl-7,8-dihydro-5H-2,6-naphthyridin-1-amine.
Procedure
Copied from the source record, unedited
The yellow residue containing 5-chloro-2-(furan-2-ylsulfonyl)-1,2,3,4-tetrahydro-2,6-naphthyridine (0.057 g, 0.19 mmol) and quinolin-3-amine (0.096 g, 0.67 mmol) from 02910-38 was dissolved in toluene (1 mL) and tert-butanol (0.170 mL). The resulting yellow solution was degassed (vacuum) and then tris(dibenzylideneacetone)dipalladium(0) (4.19 mg, 4.58 µmol), Xantphos (5.52 mg, 9.54 µmol), and sodium tert-butoxide (0.026 g, 0.27 mmol) were added. Another 2 mL of toluene and 0.340 mL of tert-butanol were also added. The resulting mixture was subjected to microwave conditions for 30 min (300W, 110°C) and then cooled. The biphasic red-brown/brown-black mixture was poured into saturated aqueous sodium chloride and extracted with ethyl acetate. The combined organic layers were dried over sodium
The source
This record comes from experimental reaction archive (ord-d1da8942a5fd4744b25120701e88bd1a). Open the source and check it against what is on this page.
experimental reaction archive record ord-d1da8942a5fd4744b25120701e88bd1a from dataset "750 AstraZeneca ELN dataset" (url: https://chemrxiv.org/engage/chemrxiv/article-details/60c9e3f37792a23bfdb2d471). No atom mapping is provided by the source.
How to read this record
This is one experiment, not a rule. It says that on one occasion these species were combined under these conditions and this came out. It does not say the reaction will give the same result on your substrate, and nothing on the page has been generalised into a claim that it would.
The pathway is a separate question, kept on separate pages. A mechanism here is the canonical arrow pushing for a class, run on real structures and labelled rule-derived. It is not evidence, and this record is not a mechanism.