Ring closure to a pyrazole

The free nitrogen of a hydrazone closes onto the carbonyl three atoms away, and the ring loses water to become an aromatic pyrazole.

mechanism writtenBalanced: every atom is accounted for

What it needs, and what it gives

Reaction class: Cyclocondensation
Typical conditions: Warm, often in acetic acid or an alcohol. The closure follows the condensation without the intermediate being isolated.
Mass balance: balanced — the co-products are written out, not dropped
Mechanism: none written

Conditions are what the literature ordinarily uses, recorded so you can see whether yours are in the usual range. They are not a procedure and they are not scaled to your flask.

How it is thought to happen

No mechanism is written for this class

The transformation is applied and tested, but no canonical pathway has been written for it yet. Rather than generate a plausible-looking set of arrows, the platform offers nothing here. What it does claim — which bonds change — is read from the transformation itself and does not depend on a mechanism.

Try it on your own structures

Enter your reactants in the Reaction Lab. If this transformation matches what you drew, it is applied and the outcome is shown next to the records that back it — with the count of documented reactions doing the same thing on substrates like yours, rather than a confidence score.

Open the Reaction Lab Browse recorded reactions