Ring closure to an isoxazole
The same closure with the oxygen of an oxime in place of the second nitrogen, giving an isoxazole.
What it needs, and what it gives
- Reaction class
- Cyclocondensation
- Warm, usually acidic.
- balanced — the co-products are written out, not dropped
- Mechanism
- none written
How it is thought to happen
The transformation is applied and tested, but no canonical pathway has been written for it yet. Rather than generate a plausible-looking set of arrows, the platform offers nothing here. What it does claim — which bonds change — is read from the transformation itself and does not depend on a mechanism.
Try it on your own structures
Enter your reactants in the Reaction Lab. If this transformation matches what you drew, it is applied and the outcome is shown next to the records that back it — with the count of documented reactions doing the same thing on substrates like yours, rather than a confidence score.
Other cyclocondensation transformations
Ring closure to a pyrazole
The free nitrogen of a hydrazone closes onto the carbonyl three atoms away, and the ring loses water to become an aromatic pyrazole.
Ring closure to a pyrrole
The nitrogen of an imine formed at one end of a 1,4-dicarbonyl closes onto the other carbonyl, losing water to give a pyrrole.