1,2-Dimethoxyethane
An ether, C4H10O2, 90.122 g/mol. Boiling point 85 °C, melting point -58 °C, as published. Appears in 67 documented reactions.
Identifiers
- Molecular formula
- C₄H₁₀O₂
- Molecular weight
- 90.122 g/mol
- Exact mass
- 90.06808 g/mol
- IUPAC name
- 1,2-dimethoxyethane
- COCCOC
- InChI=1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N
Measured properties
- Boiling Point
- 185 °F at 760 mmHg (NTP, 1992)
- 85 °C
- Melting Point
- -72 °F (NTP, 1992)
- -58 °C
- Density
- 0.868 at 68 °F (USCG, 1999) - Less dense than water; will float
- 0.86285 @ 20 °C/4 °C
- Solubility
- greater than or equal to 100 mg/mL at 72 °F (NTP, 1992)
- 1000000 mg/L (at 20 °C)
- Vapor Pressure
- 40 mmHg at 51.3 °F ; 60 mmHg at 67.5 °F (NTP, 1992)
- 48.0 [mmHg]
- LogP
- -0.21
- Log Kow = -0.21
- Flash Point
- 32 °F (NTP, 1992)
- -2 °C
Calculated properties
- Molecular weight
- 90.12 g/mol
- Exact mass
- 90.068079557 Da
- XLogP3
- -0.2
- Polar surface area
- 18.5 Ų
- Complexity
- 17
- H-bond donors
- 0
- H-bond acceptors
- 2
- logP
- 0.2792
- Topological polar surface area
- 18.46 Ų
- H-bond donors
- 0
- H-bond acceptors
- 2
- Rotatable bonds
- 3
- Molar refractivity
- 23.752 cm³/mol
- Fraction sp³ carbons
- 1
- QED drug-likeness
- 0.4633
What it is made of
Elements
Structure
- Heavy atoms, hydrogen excluded
- 6
- Total atoms, hydrogen included
- 16
- Rings
- 0
- Aromatic rings
- 0
- Stereocentres
- 0
- Formal charge
- 0
Functional groups
Ether
The molecule in three dimensions
The drawing above is a diagram of what is bonded to what. A molecule is not flat, and the model here is one low-energy shape generated from the connectivity — useful for seeing which groups can reach each other, and not a measured structure. A real sample is a population of conformations, interconverting.
Reactions it appears in
67 documented reactions involve 1,2-Dimethoxyethane, each with a written procedure and a source, and all of them are buchwald–hartwig amination. A few are shown.
Buchwald–Hartwig amination
Buchwald–Hartwig amination · as a solvent
A recorded experiment with its conditions, its yield where one was published, and a link to the source.
Buchwald–Hartwig amination
Buchwald–Hartwig amination · as a solvent
A recorded experiment with its conditions, its yield where one was published, and a link to the source.
Buchwald–Hartwig amination
Buchwald–Hartwig amination · as a solvent
A recorded experiment with its conditions, its yield where one was published, and a link to the source.
Other names for it
The systematic name on this record is 1,2-dimethoxyethane.
The sources also call it Monoglyme, Ethylene glycol dimethyl ether, Glyme, Dimethyl Cellosolve, Dimethoxyethane, Egdme, 2,5-Dioxahexane, Ethane, 1,2-dimethoxy-, Glycol dimethyl ether, Dimethylcellosolve, Hisolve MMM.
Structurally related
Seen alongside it in reaction records
Molecules that appear in the same recorded reactions as 1,2-Dimethoxyethane. This says nothing about structure: most of them are the bases, solvents, ligands and catalysts the chemistry needed, and they are here because somebody put them in the same flask.
1,8-Diazabicyclo(5.4.0)undec-7-ene
used as a reactant
C₉H₁₆N₂, 152.241 g/mol.
(4-Methoxyphenyl)boronic acid
used as a reactant
C₇H₉BO₃, 151.958 g/mol.
(R)-(-)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi-t-butylphosphine;Ferrocene, 1-[(1R)-1-[bis(1,1-dimethylethyl)phosphino]ethyl]-2-(dicyclohexylphosphino)-, (2R)-
C₃₂H₆₂FeP₂, 564.641 g/mol.
(Pyridin-4-yl)boronic acid
used as a reactant
C₅H₆BNO₂, 122.92 g/mol.
Where these values came from
chemistry engine
What this page does not claim
Identifiers are copied from the source record, measured values are reported as published, and calculated values are marked as calculated. Nothing here is a hazard, purity or handling assessment — how the library is checked.
Where to next
More molecules under 0–9
The rest of this shelf, a hundred names at a time.
Molar mass calculator
Work with C4H10O2 in a calculation, with every element's contribution shown.
Molarity calculator
Grams of 1,2-Dimethoxyethane for a volume and a concentration, or the concentration a mass gives.
Open in ReactionLens
The full record in the workstation: every atom, every bond, and the reactions it appears in.