Acylation
Recorded reactions filed under this class. The ones that carry a written procedure and an atom map are shown below as worked examples.
How it is thought to work
The nucleophile adds to the carbonyl, the carbon holds four groups for a moment, and the leaving group is pushed out as the double bond comes back.
What the engine will do with your structures
Acyl chloride with an amine
The amine displaces chloride from the carbonyl, giving the amide. Usually run: Cold, often with a base to take up the hydrogen chloride.
Acyl chloride with an alcohol
The alcohol displaces chloride from the carbonyl, giving the ester. Usually run: Often with pyridine or another base present.
Worked examples
Reading these records
Everything on a record page came from the source that published it. Conditions the source did not state are shown as not recorded, and no typical value is substituted for them. Yields are whatever was measured by whoever ran the experiment.
Other classes
Buchwald–Hartwig amination
Recorded reactions with their conditions, and worked examples where a procedure and atom map were published.
Suzuki–Miyaura coupling
Recorded reactions with their conditions, and worked examples where a procedure and atom map were published.
Reductive amination
Recorded reactions with their conditions, and worked examples where a procedure and atom map were published.
Mizoroki–Heck reaction
Recorded reactions with their conditions, and worked examples where a procedure and atom map were published.
Imidazole arylation
Recorded reactions with their conditions, and worked examples where a procedure and atom map were published.
Buchwald–Hartwig etherification
Recorded reactions with their conditions, and worked examples where a procedure and atom map were published.